Endocrinology, Diabetes and Metabolism Community Participation:
Thanks to Carrie Burns for organizing our inaugural meeting, which was attended by ~15medical students.
Javier Ocampo Mascaro, gave a lecture on GLP-1 medications. Natalie Dapas and Raashi Mamtani gave a Thyroid Chalk Talk.
Publications
Mitch Lazar:
Woodie LN, Alberto AJ, Krusen BM, Melink LC, Lazar MA. Genetic
synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2417678121.
doi: 10.1073/pnas.2417678121. Epub 2024 Dec 12. PMID: 39665757; PMCID:PMC11665897.
Mike Rickels, Austin Matus, Amy Peleckis, Jorge Jo Kamimoto:
Kudva YC, Henderson RJ, Kanapka LG, Weinstock RS, Rickels MR, Pratley RE, Chaytor N, Janess K, Desjardins D, Pattan V, Peleckis AJ, Casu A, Rizvi SR, Bzdick S, Whitaker KJ, Jo Kamimoto JL, Miller K, Kollman C, Beck RW. Automated Insulin Delivery in Older Adults with Type 1 Diabetes. NEJM Evid. 2025 Jan;4(1):EVIDoa2400200. doi: 10.1056/EVIDoa2400200. Epub 2024 Dec 23.PMID: 39714936
Publication led by Rickels post-doctoral research fellow Austin:
Matus AM, Riegel B, Rickels MR. Interoceptive Awareness Is Associated With Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes.Diabetes Care. 2025 Jan 1;48(1):101-105. doi: 10.2337/dc24-1720.PMID: 39546638
Publication contributed to by Rickels post-doctoral fellows Austin and Anneliese:
Lin YK, Ye W, Hepworth E, Agni A, Matus AM, Flatt AJ, Shaw JAM, Rickels MR, Amiel SA, Speight J. Characterising impaired awareness of hypoglycaemia and associated risks through HypoA-Q: findings from a T1D Exchange cohort.Diabetologia. 2025 Feb;68(2):433-443. doi: 10.1007/s00125-024-06310-5. Epub 2024 Oct 30.PMID: 39477881
Collaboration with CHOP Endocrine Division:
Tamaroff J, Nguyen S, Wilson NE, Stefanovski D, Xiao R, Scattergood T, Capiola C, Schur GM, Dunn J, Dedio A, Wade K, Shah H, Sharma R, Mootha VK, Kelly A, Lin KY, Lynch DR, Reddy R, Rickels MR, McCormack SEInsulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle. J Clin Endocrinol Metab. 2025 Jan 21;110(2):317-333. doi: 10.1210/clinem/dgae545.PMID: 39109797
Jeremy Flood:
Characterization of Interchanging Incretin Analogs in Clinical Practice: A Descriptive Report. Hvisdas CM, Goode ND, Kim DH, Silvey MJ, Flood JJ.Endocr Pract. 2024 Oct 15: S1530-891X (24)00795-X. doi: 10.1016/j.eprac.2024.09.117. Epub ahead of print. PMID: 39414234.
Mitch Lazar:
Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake. Woodie LN, Melink LC, Midha M, de Araújo AM, Geisler CE, Alberto AJ, Krusen BM, Zundell DM, de Lartigue G, Hayes MR, Lazar MA. Science. 2024 Nov 8;386(6722):673-677. doi: 10.1126/science. adn2786. Epub 2024 Nov 7. PMID: 39509517.
This paper was featured on the Penn Medicine news release:
https://www.pennmedicine.org/news/news-releases/2024/november/new-study-links-liver-brain-communication-to-daily-eating-patterns
There is also a perspective article in the same issue of Science to accompany the paper
https://www.science.org/doi/10.1126/science.adt0743
Mike Rickels:
Online Classification of Unstructured Free-Living Exercise Sessions in People with Type 1 Diabetes.
Fushimi E, Aiello EM, Cho S, Riddell MC, Gal RL, Martin CK, Patton SR, Rickels MR, Doyle FJ 3rd.Diabetes Technol Ther. 2024 Oct;26(10):709-719. doi: 10.1089/dia.2023.0528. Epub 2024 May 24. PMID: 38417016
Prolonged Use of an Automated Insulin Delivery System Improves Sleep in Long-Standing Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia.
Malone SK, Matus AM, Flatt AJ, Peleckis AJ, Grunin L, Yu G, Jang S, Weimer J, Lee I, Rickels MR, Goel N.J Diabetes Sci Technol. 2024 Nov;18(6):1416-1423. doi: 10.1177/19322968231182406. Epub 2023 Jul 14. PMID: 37449426
Congratulations to Austin Matus for receiving the Marth N. Hill Early Career Investigator Award from the American Heart Association.
Austin is an RN, PhD, Postdoctoral Researcher working in Dr. Michael Rickels Research Lab.
Endocrinology, Diabetes and Metabolism Community Participation remains strong!
Members of the EDM Community, Jasmine Hudson and Family, Carrie Burns, and Maria Alesi Hannold (pictured right to left) participated in the Breakthrough Type 1 Diabetes Walk.
Congratulations to Anne R. Cappola for For receiving the Women in Thyroidology Woman of the Year Award.
The Woman of the Year is selected based on her long-standing commitment to the ATA and the advancement of women both within the organization and in the thyroid field.
EDM Community Participation:
ADA STEP OUT WALK to Stop Diabetes—very visible Penn EDM presence!
October 19, 2024 Navy Yard Marine Parade Grounds
Photos below of our faculty and staff who participated including Carrie Burns, Caitlin White, Jasmine Hudson, Zena Harrison, Enjoli Barnes, Erika Tapino, Austin Matus, Mark Schutta, Michelle Walker, Natalie Dapas.
Thanks to Kevin Mahoneyfor sponsoring the Penn Rodebaugh table, see the signs for Penn Medicine and EDM!
Community Pillar participates in the Penn Medicine Community Day
Meet 2024 Celebrate Caring Winners (ibx.com)
New EDM Fellows who will be with us through June 2026
Taking Charge of Your Diabetes: An Educational Series
Join us for one or all of these educational events that will help you understand and manage your diabetes. This is a 3-part series being hosted by The Community of Compassion CDC located at 6150 Cedar Ave. in West Philadelphia. Refreshments and Giveaways will be provided!
Live Virtual Course - Foundations of Culinary Medicine for Healthcare Professionals
Dr. Carrie Burns will once again lead a discussion geared at medical providers that will focus on healthy food choice for patients with diabetes. This is part of a Culinary Medicine course. Foundations of Culinary Medicine is structured to educate medical providers about the importance of healthy food and nutrition, while giving them the skills and tools by which they can assist their patients (as well as themselves) lead healthier lives. You can register using this link.
Endocrine Society's 2023 Early Career Forum Awards
The Early Career Forum is a prestigious program offered exclusively to graduate and medical students, postdoctoral and clinical fellows, and internal medicine residents.
Endocrine Society's 2023 Laureate Awards
Mitch Lazar is the recipient of the Fred Conrad Koch Lifetime Achievement Award—the Society’s highest honor. This recognizes the lifetime achievements and exceptional contributions of an individual to the field of endocrinology.
Peter Snyder is the recipient of the Outstanding Clinical Investigator Award, which is presented to an internationally-recognized clinical investigator for meritorious contributions to clinical research related to pathogenesis, pathophysiology, and therapy of endocrine diseases.
Recent Publications
This paper identifies composite metrics that can be used to predict individuals with absent autonomic symptom (AS) recognition and defective glucose counterregulation during insulin-induced hypoglycemia.
This is a systematic review of the literature and an individual participant data analysis of multiple prospective cohorts to investigate the association between subclinical thyroid dysfunction and incident diabetes, including primary data from cohorts Anne works with (the Cardiovascular Health Study). Findings-- no association between subclinical thyroid dysfunction and incident diabetes
This review examines a trend in the field we are seeing as well at Penn Medicine with insulin deficient subtypes of type 2 diabetes being considered candidates for pancreas transplantation that had traditionally been limited to type 1 diabetes.
This review article summarizes what is known about the circadian rhythmicity of nutrient metabolism and discusses obesity as a circadian disease.
Brown adipose tissue (BAT) helps mammals survive in the cold (really important in hibernation!) by producing heat through burning of calories. This paper helps to elucidate the physiologic functions of transcriptiomal coregulator complexes.
New Patient Education Videos
The Fall 2022 IDOM/DRC Seminar Series
View our event calendar
2022 New Endocrinology Fellows
Visit our News Archive page for past announcements about the Division.
Former and Current Fellows
Congratulations
Philadelphia Magazine's Top Docs™
Castle Connolly Top Docs for 2022
We are excited to announce the Castle Connolly Top Doctors for 2022! For over 25 years, Castle Connolly has been proud to be the most trusted resource in identifying Top Doctors, a recognition that only goes to the top 7% of all US board-certified physicians.
Publications
Mike Rickels in collaboration with the Advocacy Committee chaired by Dr. Susan Mandel for the International Pancreas and Islet Transplant Association:
International Survey of Clinical Monitoring Practices in Pancreas and Islet Transplantation. This pragmatic report identifies common monitoring strategies utilized following pancreas and islet transplantation and can therefore serve as a guidance document for developing monitoring algorithms following beta-cell replacement..
A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas | Development | The Company of Biologists
This work expands our knowledge of the role of the transcription factor PDX1 in pancreas development
JCI - α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals
This paper reports that α cell dysfunction was present during the early stages of islet autoimmunity at a time when β cell mass was still normal, raising important questions about the role of early α cell dysfunction in the progression of T1Diabetes.
